L03 Secretions of Stomach

• Functions of Stomach

Cells & Secretions

• Mucous Neck: Mucous + Bicarbonate
• Parietal(Oxyntic): Hydrochloric Acid + Intrinsic Factor
  • Intrinsic Factor for B12 Absorption in Terminal Ileum
• Enterochromaffin Like (EC-Like): Histamine
  • Stimulates Acid Production
• Chief Cell: Pepsinogen + Gastric Lipase
• D Cell: Somatostatin
  • Inhibits Acid Production
    • Antagonist to AC Pathway in Parietal Cells
• G Cell: Gastrin
  • Stimulates Acid Production
• Locations Of Cells

Acid Secretion

Parietal Cell - $\ce{H+/K+}$ Pump

Apical Membrane

Alpha Subunit (Catalytic), Beta Subunit (Membrane Targeting)

Active - Requires ATP

• Process
• Control
• Somatostatin
• Gastrin
• Other Inhibitors

Pharmacology Acid Secretion

Treat: Peptic Ulcer Disease, GORD, Barrett’s Dyspepsia, Zollinger-Ellison Syndrome